In this article the method of generation and reception of novel multicarrier M-ary orthogonal chaotic spread spectrum signals (MC-MO-CSSS) with size of signal ensemble from 2 up to 256 and more is supposed. The analysis of some MC-MO-CSSS properties is carried out. The structure of MC-MO-CSSS modulator-demodulator which can be used for deployment of both 3rd generation and 4th generation communication systems is offered. Results of computer simulations for MC-MO-CSSS are shown. Adequacy of computer model is proven by means of comparison of the reception noise immunity estimation against white Gaussian noise for the channel with the constant parameters. The new approach of comb noise rejection at MC-MO-CSSS reception has been approved. Results of the reception noise immunity estimation which have been given for a various number of affected MC-MO-CSSS subcarriers confirm efficiency of the offered approach.