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ALGORITHM FOR CUMULATIVE CALCULATION OF GENE SET ENRICHMENT STATISTIC

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Methods for gene set enrichment analysis, widely-used for analysis of gene expression data, were studied. A problem of cumulative calculation of enrichment statistic was considered. For this problem an algorithm based on square root decomposition heuristic was developed. An asymptotic run-time complexity of the algorithm was found. Practical implementation showed an order of magnitude increase in performance compared to a naïve algorithm when run on typical input sizes. The developed algorithm can be used to improve significantly the performance of gene set enrichment analysis.

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