For example,Бобцов

MULTI-CHAMBER APPARATUS WITH A CONVEYOR MAGNETIC DRIVE FOR DETERMINING THE KINETICS OF DISSOLUTION OF PHARMACEUTICAL FORMS

Annotation

It is obvious for both drug developers and manufacturers, that the solubility of various pharmaceutical forms is very important for the delivery of active substances; in addition, this characteristic is used in the standard method of quality control in production. Methods for testing the solubility of various pharmaceuticals require expensive, mostly imported, equipment with a small number of simultaneously used solution containers. The presented device for testing solubility uses the principle of magnetically activated mixing and contains twelve tanks (reservoirs) mounted in a thermostat. A moving magnetic field, generated either by the windings of electromagnets or by permanent magnets moving on a conveyor or on a disk along the tanks, affects the standard agitators with the dissolution medium located in each tank. In order to confirm the satisfactory coincidence of the physical and chemical processes occurring in all containers, the model of the device was created and tested for the simultaneous digestion of such samples as coated tablets and gelatin-based capsules. To check the obtained results, three types of buffer solutions and distilled water were used as a solvent liquid, and the method of comparing the luminescence intensity and measuring the acidity of the samples was used in the analysis of the dissolution kinetics. Good reproducibility of the measurement results showed similar parameters of digestion process provided by the device.

Keywords

Постоянный URL

Articles in current issue

CONTENT © ITMO UNIVERSITY 1993-2024