APPLICATION OF THE TOTAL INTERNAL REFLECTION METHOD FOR THE STUDY OF LIQUID-PHASE MEDIUM BASED ON BOTULINUM TOXIN
Annotation
Application of the total internal reflection method for the study of liquid-phase media based on botulinum toxin is considered. A comparative analysis of these drugs is carried out. Structural and functional scheme, as well as technical and operational characteristics of the developed refractometric system are presented. Botulinum toxin-based drugs - Botox, Xeomin, and Dysport - are used as objects of research. Experimental results of measurements of the concentration dependences of the refractive index in these preparations are obtained. It is shown that temperature dependences for Botox, Xeomin, and Dysport at various concentrations make it possible to change the algorithm of temperature correction of refractometric data.
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